Ro 46-2005

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ro 46-2005是第一个合成的口服活性内皮素受体非肽拮抗剂，对ETA和ETB具有等效效力（IC50=0.2-0.5 uM）。

Ro 46-2005 is the first synthetic orally active nonpeptide antagonist of endothelin receptor with equipotent potency (IC50=0.2-0.5 uM) for ETA and ETB; has no effect on plasma concentrations of big ET-1 and only a minor effect on those of ET-3; sufficient to inhibit the pressor effect of the precursor big ET-1 at much lower doses (1 to 10 mg/kg i.v.).Hypertension Preclinical.

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Ro-462005

GPCR/G Protein

Endothelin Receptor

ET-A|ET-B

Cardiovascular Disease

Hypertension

150725-87-4

473.542

C23H27N3O6S

>98% (HPLC)

DMSO: ≥ 28 mg/mL

O=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=NC=NC(OCCO)=C2OC3=CC=CC(OC)=C3)=O

Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]-

(-20℃)

With Ice Pack

≥ 2 years